Penicillin-binding protein 2B
Details
- Name
- Penicillin-binding protein 2B
- Synonyms
- pbp2b
- Gene Name
- penA
- UniProtKB Entry
- P0A3M6Swiss-Prot
- Organism
- Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
- NCBI Taxonomy ID
- 171101
- Amino acid sequence
>lcl|BSEQ0006970|Penicillin-binding protein 2B MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSAR GEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYY LADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEIYLFSQ LNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE KAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIE EGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSG IKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVFQGSAP INSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRS TFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGV RVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTT GRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNG VGPSIARDIINLYQKYHPMN
- Number of residues
- 680
- Molecular Weight
- 73872.305
- Theoretical pI
- 4.85
- GO Classification
- Functionspenicillin bindingProcessescell wall organization / peptidoglycan biosynthetic process / regulation of cell shape / response to antibioticComponentsintegral component of membrane / plasma membrane
- General Function
- A transpeptidase that forms peptide cross-links between adjacent glycan strands in cell wall peptidoglycan (PG). Part of the elongasome machinery that synthesizes peripheral PG.
- Specific Function
- penicillin binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 9-29
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017168|Penicillin-binding protein 2B (penA) ATGAGACTGATTTGTATGAGAAAATTTAACAGCCATTCGATTCCGATTCGGCTTAATTTA TTGTTTTCAATCGTCATTTTACTCTTTATGACCATTATTGGTCGTTTGTTGTATATGCAG GTTTTGAACAAGGATTTTTACGAAAAAAAGCTAGCCTCAGCTAGTCAGACCAAGATTACA AGCAGTTCAGCCCGTGGGGAAATTTATGATGCTAGTGGAAAACCTTTGGTAGAAAATACG TTAAAGCAGGTTGTTTCCTTTACGCGTAGCAATAAAATGACGGCTACAGACTTAAAAGAA ACAGCTAAAAAGTTACTGACTTATGTGAGCATCAGTTCTCCAAATTTGACAGAACGCCAG CTGGCGGATTACTATTTGGCTGATCCTGAAATCTATAAAAAAATAGTGGAAGCTCTCCCA AGCGAGAAACGCTTGGATTCAGATGGCAATCGTCTATCCGAATCAGAACTGTATAACAAT GCGGTCGATAGTGTACAAACGAGTCAACTAAACTATACAGAGGATGAAAAGAAAGAAATC TATCTTTTTAGTCAGTTAAATGCTGTTGGAAACTTTGCGACAGGAACCATTGCTACAGAT CCTCTAAATGATTCTCAGGTGGCTGTTATTGCCTCTATTTCAAAGGAGATGCCTGGCATT AGTATTTCTACTTCTTGGGATAGAAAGGTTTTGGAAACTTCCCTTTCTTCTATAGTTGGG AGTGTATCCAGTGAAAAAGCTGGTCTCCCAGCGGAAGAAGCAGAAGCCTATCTTAAAAAA GGCTATTCTCTAAATGACCGTGTAGGAACCTCCTATTTGGAAAAGCAATATGAAGAGACC TTACAAGGAAAACGCTCGGTAAAAGAAATCCATCTGGATAAATATGGCAATATGGAAAGC GTGGATACAATTGAGGAAGGTAGTAAGGGAAACAATATCAAACTGACCATTGATTTGGCT TTCCAAGATAGCGTGGATGCTTTACTGAAAAGTTATTTCAATTCTGAGCTAGAAAATGGT GGAGCCAAGTATTCTGAAGGTGTCTATGCAGTCGCCCTTAACCCAAAAACAGGTGCGGTT TTGTCTATGTCAGGGATTAAACATGACTTGAAAACGGGAGAGTTGACGCCTGATTCCTTG GGAACGGTAACCAATGTCTTTGTTCCAGGTTCGGTTGTCAAGGCGGCGACCATCAGCTCA GGTTGGGAAAATGGAGTCTTGTCAGGAAACCAGACCTTGACAGACCAGTCCATTGTCTTC CAAGGTTCAGCTCCCATCAATTCTTGGTATACTCAGGCTTACGGTTCATTCCCTATCACA GCGGTCCAAGCTCTGGAGTATTCATCAAATACCTATATGGTCCAAACAGCCTTAGGTCTT ATGGGGCAAACCTATCAACCCAATATGTTTGTCGGCACCAGCAATCTAGAGTCTGCTATG GAGAAACTGCGTTCAACCTTTGGCGAATATGGCTTGGGTACTGCGACAGGAATTGACCTA CCAGATGAATCTACTGGATTTGTTCCCAAAGAGTATAGCTTTGCTAATTACATTACTAAT GCCTTTGGGCAGTTTGATAACTATACGCCGATGCAGTTGGCTCAGTATGTAGCAACTATT GCAAATAATGGTGTTCGTGTGGCTCCTCGTATTGTTGAAGGCATTTATGGTAATAATGAT AAGGGAGGACTGGGTGACTTGATTCAGCAACTGCAACCGACAGAGATGAATAAGGTCAAT ATATCCGACTCCGATATGAGCATCTTGCACCAAGGTTTTTATCAGGTTGCCCATGGTACT AGTGGATTGACAACTGGACGTGCCTTTTCAAATGGTGCCTTGGTATCCATTAGCGGAAAA ACAGGTACAGCCGAAAGCTATGTGGCAGATGGTCAGCAAGCAACCAATACCAATGCGGTG GCCTATGCCCCATCTGATAATCCCCAAATCGCTGTCGCAGTGGTCTTTCCTCATAATACC AATCTAACAAATGGTGTAGGACCTTCCATTGCGCGTGACATTATCAATCTGTATCAAAAA TACCATCCAATGAATTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A3M6 UniProtKB Entry Name PBP2_STRR6 GenBank Protein ID 984233 GenBank Gene ID X16022 PDB ID(s) 2WAD, 2WAE, 2WAF KEGG ID spr:spr1517 NCBI Gene ID 933948 - General References
- Dowson CG, Hutchison A, Spratt BG: Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6. Nucleic Acids Res. 1989 Sep 25;17(18):7518. [Article]
- Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI: Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17. [Article]
- Dowson CG, Hutchison A, Spratt BG: Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae. Mol Microbiol. 1989 Jan;3(1):95-102. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Penicillin-binding protein 2B (Streptococcus pneumoniae (strain ATCC BAA-255 / R6)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Cefditoren approved, investigational yes target inhibitor Details Ceftriaxone approved yes target inhibitor Details Cefadroxil approved, vet_approved, withdrawn yes target inhibitor Details Cefotaxime approved yes target inhibitor Details Piperacillin approved yes target inhibitor Details Nafcillin approved, investigational yes target inhibitor Details Ampicillin approved, vet_approved yes target inhibitor Details Dicloxacillin approved, investigational, vet_approved yes target inhibitor Details Amdinocillin investigational, withdrawn yes target inhibitor Details Meticillin approved, investigational yes target inhibitor Details Cefalotin approved, investigational, vet_approved yes target inhibitor Details Oxacillin approved, investigational yes target inhibitor Details Cefoxitin approved yes target inhibitor Details Cephalexin approved, investigational, vet_approved yes target inhibitor Details Cephalosporin C experimental yes target inhibitor Details Azidocillin experimental yes target inhibitor Details Hetacillin approved, vet_approved, withdrawn yes target inhibitor Details Ceftobiprole medocaril approved, experimental, investigational yes target inhibitor Details Ceftobiprole approved, investigational yes target inhibitor Details