ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.

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Vu AT, Campbell AN, Harris HA, Unwalla RJ, Manas ES, Mewshaw RE

ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.

PubMed ID

17482813 [ View in PubMed

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Abstract

A new class of estrogen receptor beta (ERbeta) ligands based on the 6H-chromeno[4,3-b]quinoline scaffold has been prepared. Several C7-substituted analogues displayed high affinity and modest selectivity for ERbeta.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Genistein	Steroid hormone receptor ERR1	IC 50 (nM)	10	N/A	N/A	Details