Development of potent and selective dipeptidyl peptidase II inhibitors.

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Senten K, Van der Veken P, Bal G, De Meester I, Lambeir AM, Scharpe S, Bauvois B, Haemers A, Augustyns K

Development of potent and selective dipeptidyl peptidase II inhibitors.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2825-8.

PubMed ID

12270155 [ View in PubMed

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Abstract

Structure-activity investigations of product-like dipeptide analogues lacking the C-terminal carbonyl function resulted in potent and selective dipeptidyl peptidase II (DPP II) inhibitors. Dab-Pip has an IC(50)=0.13 microM for DPP II and a 7600-fold selectivity with respect to DPP IV. This compound will be highly valuable for the investigation of the biochemical function of DPP II.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One	Dipeptidyl peptidase 4	IC 50 (nM)	4000	N/A	N/A	Details