Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.

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Levin JI, Gu Y, Nelson FC, Zask A, DiJoseph JF, Sharr MA, Sung A, Jin G, Cowling R, Chanda P, Cosmi S, Hsiao CL, Edris W, Wilhelm J, Killar LM, Skotnicki JS

Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.

Bioorg Med Chem Lett. 2001 Jan 22;11(2):239-42.

PubMed ID

11206468 [ View in PubMed

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Abstract

Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
WAY-151693	Collagenase 3	IC 50 (nM)	8	N/A	N/A	Details