Design and synthesis of conformationally-constrained MMP inhibitors.

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Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG, Bradley RS, Taiwo YO, Mieling GE, Dunaway CM, Snider CE, McIver JM, Barnett BL, McPhail SJ, Anastasio MB, De B

Design and synthesis of conformationally-constrained MMP inhibitors.

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80.

PubMed ID

9873489 [ View in PubMed

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Abstract

A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor	Stromelysin-1	IC 50 (nM)	104	N/A	N/A	Details