Stromelysin-1

BE0001116ProteinHumansMMP3

Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. It is acted on by 29 drugs in DrugBank.

Gene name
MMP3
UniProtKB entry
P08254Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
477 residues · 53,977 Da
Also known as
3.4.24.17 · Matrix metalloproteinase-3 · MMP-3 · SL-1 · STMY1

Resolves to

Protein
UniProtP08254UniProt nameMMP3_HUMAN
Gene
HGNCHGNC:7173NCBI Gene4314GenBank36633GeneCardsMMP3
Pharmacology
IUPHAR/GtoPdb1630KEGGhsa:4314
Structure
PDB1B3DPDB1B8YPDB1BIW
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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86+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Stromelysin-1, and which indications are they being tested in?

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