Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

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McCluskey A, Sim AT, Sakoff JA

Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

J Med Chem. 2002 Mar 14;45(6):1151-75.

PubMed ID

11881984 [ View in PubMed

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Abstract

Not Available

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
9,10-Deepithio-9,10-Didehydroacanthifolicin	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	IC 50 (nM)	28	N/A	N/A	Details
9,10-Deepithio-9,10-Didehydroacanthifolicin	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	IC 50 (nM)	>5000	N/A	N/A	Details
9,10-Deepithio-9,10-Didehydroacanthifolicin	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	IC 50 (nM)	48	N/A	N/A	Details
9,10-Deepithio-9,10-Didehydroacanthifolicin	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	IC 50 (nM)	45	N/A	N/A	Details
9,10-Deepithio-9,10-Didehydroacanthifolicin	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	IC 50 (nM)	1150	N/A	N/A	Details
9,10-Deepithio-9,10-Didehydroacanthifolicin	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	IC 50 (nM)	78	N/A	N/A	Details
9,10-Deepithio-9,10-Didehydroacanthifolicin	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	IC 50 (nM)	260	N/A	N/A	Details