3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.

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Beaton H, Hamley P, Nicholls DJ, Tinker AC, Wallace AV

3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1023-6.

PubMed ID

11327580 [ View in PubMed

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Abstract

3-Phenyl-3.4-dihydro-1-isoquinolinamine is a weak inhibitor of iNOS and nNOS. Structural variation of 5a results in inhibitors with a range of potency and selectivity for the NOS enzymes, including a potent and very selective iNOS inhibitor 5j.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Pimagedine	Nitric oxide synthase, inducible	IC 50 (nM)	4500	N/A	N/A	Details
Pimagedine	Nitric oxide synthase, inducible	IC 50 (nM)	1100000000	N/A	N/A	Details