Nitric oxide synthase, inducible

BE0000005ProteinHumansNOS2

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). It is acted on by 63 drugs in DrugBank.

Gene name
NOS2
UniProtKB entry
P35228Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,153 residues · 131,116 Da
Also known as
1.14.13.39 · HEP-NOS · Hepatocyte NOS · Inducible NO synthase · Inducible NOS

Resolves to

Protein
UniProtP35228UniProt nameNOS2_HUMAN
Gene
HGNCHGNC:7873NCBI Gene4843GenBank292242GeneCardsNOS2
Pharmacology
IUPHAR/GtoPdb1250KEGGhsa:4843
Structure
PDB1NSIPDB2LL6PDB2NSI
Drugs

What you can answer from here — as of September 07, 2019

63DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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195+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nitric oxide synthase, inducible, how selective are they, and which programs against it are still in active trials?

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