Design of enzyme inhibitors using iterative protein crystallographic analysis.

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Appelt K, Bacquet RJ, Bartlett CA, Booth CL, Freer ST, Fuhry MA, Gehring MR, Herrmann SM, Howland EF, Janson CA, et al.

Design of enzyme inhibitors using iterative protein crystallographic analysis.

J Med Chem. 1991 Jul;34(7):1925-34.

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2066965 [ View in PubMed

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
10-Propargyl-5,8-Dideazafolic Acid	Thymidylate synthase	Ki (nM)	12	N/A	N/A	Details