Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies.

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Khattab SN, Hassan SY, Bekhit AA, El Massry AM, Langer V, Amer A

Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies.

Eur J Med Chem. 2010 Oct;45(10):4479-89. doi: 10.1016/j.ejmech.2010.07.008. Epub 2010 Jul 21.

PubMed ID

20708306 [ View in PubMed

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Abstract

A series of 2-benzyl-3-(2-arylidenehydrazinyl)quinoxalines 3, 4-benzyl-1-aryl-[1,2,4]triazolo[4,3-a]quinoxalines 4 and phenyl(1-aryl-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl)methanones 5 analogues were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. The inhibition profile was found to be competitive for compounds 3k, 3m, 5f and 5n with MAO-A selectivity. Observation of the docked positions of these compounds revealed interactions with many residues previously reported to have an effect on the inhibition of the enzyme. The structural features of the new compounds have been determined from the microanalytical, IR, (1)H, (13)C NMR spectral studies and X-ray crystalography.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Clorgiline	Amine oxidase [flavin-containing] A	IC 50 (nM)	3.1	N/A	N/A	Details