Amine oxidase [flavin-containing] A

BE0002198ProteinHumansMAOA

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the... It is acted on by 86 drugs in DrugBank.

Gene name
MAOA
UniProtKB entry
P21397Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
527 residues · 59,681 Da
Also known as
1.4.3.21 · 1.4.3.4 · MAO-A · Monoamine oxidase type A

Resolves to

Protein
UniProtP21397UniProt nameAOFA_HUMAN
Gene
HGNCHGNC:6833NCBI Gene4128GenBank187353GeneCardsMAOA
Pharmacology
IUPHAR/GtoPdb2489KEGGhsa:4128
Structure
PDB2BXRPDB2BXSPDB2Z5X
Drugs

What you can answer from here — as of September 07, 2019

86DrugsApproved to experimental, with action, bond type and pharmacological action
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15Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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240+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Amine oxidase [flavin-containing] A, how selective are they, and which programs against it are still in active trials?

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