Long-acting peptidomimetics based DPP-IV inhibitors.
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Jadav P, Bahekar R, Shah SR, Patel D, Joharapurkar A, Kshirsagar S, Jain M, Shaikh M, Sairam KV
Long-acting peptidomimetics based DPP-IV inhibitors.
Bioorg Med Chem Lett. 2012 May 15;22(10):3516-21. doi: 10.1016/j.bmcl.2012.03.078. Epub 2012 Mar 28.
- PubMed ID
- 22503246 [ View in PubMed]
- Abstract
Pyrrolidine based peptidomimetics are reported as potent and selective DPP-IV inhibitors for the treatment of T2DM. Compounds 16c and 16d showed excellent in vitro potency and selectivity towards DPP-IV and the lead compound 16c showed sustained antihyperglycemic effects, along with improved pharmacokinetic profile.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Vildagliptin Dipeptidyl peptidase 4 IC 50 (nM) 3.2 N/A N/A Details