Long-acting peptidomimetics based DPP-IV inhibitors.

Article Details

Citation

Jadav P, Bahekar R, Shah SR, Patel D, Joharapurkar A, Kshirsagar S, Jain M, Shaikh M, Sairam KV

Long-acting peptidomimetics based DPP-IV inhibitors.

Bioorg Med Chem Lett. 2012 May 15;22(10):3516-21. doi: 10.1016/j.bmcl.2012.03.078. Epub 2012 Mar 28.

PubMed ID
22503246 [ View in PubMed
]
Abstract

Pyrrolidine based peptidomimetics are reported as potent and selective DPP-IV inhibitors for the treatment of T2DM. Compounds 16c and 16d showed excellent in vitro potency and selectivity towards DPP-IV and the lead compound 16c showed sustained antihyperglycemic effects, along with improved pharmacokinetic profile.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
VildagliptinDipeptidyl peptidase 4IC 50 (nM)3.2N/AN/ADetails