Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.

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Fujieda H, Usui S, Suzuki T, Nakagawa H, Ogura M, Makishima M, Miyata N

Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4351-7. Epub 2007 May 13.

PubMed ID

17524643 [ View in PubMed

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Abstract

To find novel PPARdelta-selective agonists, we designed and synthesized phenylpropanoic acid derivatives bearing 6-substituted benzothiazoles. Optimization of this series led to the identification of a potent and selective PPARdelta agonist 17. Molecular modeling suggested that compound 17 occupies the Y-shaped pocket of PPARdelta appropriately.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Cardarine	Peroxisome proliferator-activated receptor delta	EC 50 (nM)	85	N/A	N/A	Details