Peroxisome proliferator-activated receptor delta

Details

Name
Peroxisome proliferator-activated receptor delta
Kind
protein
Synonyms
  • NR1C2
  • NUC1
  • NUCI
  • Nuclear hormone receptor 1
  • Nuclear receptor subfamily 1 group C member 2
  • Peroxisome proliferator-activated receptor beta
  • PPAR-beta
  • PPAR-delta
  • PPARB
Gene Name
PPARD
UniProtKB Entry
Q03181Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0002005|Peroxisome proliferator-activated receptor delta
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
Number of residues
441
Molecular Weight
49902.99
Theoretical pI
7.65
GO Classification
Functions
DNA binding / linoleic acid binding / lipid binding / zinc ion binding
Processes
adipose tissue development / apoptotic process / apoptotic signaling pathway / axon ensheathment / cell differentiation / cell-substrate adhesion / cellular response to hypoxia / cholesterol metabolic process / decidualization / embryo implantation / fatty acid beta-oxidation / fatty acid catabolic process / fatty acid transport / generation of precursor metabolites and energy / glucose metabolic process / keratinocyte migration / keratinocyte proliferation / lipid metabolic process / negative regulation of epithelial cell proliferation / negative regulation of myoblast differentiation / positive regulation of fat cell differentiation / positive regulation of myoblast proliferation / positive regulation of skeletal muscle tissue regeneration / wound healing
Components
nucleoplasm / nucleus
General Function
Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826). Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand
Specific Function
Dna binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0019047|Peroxisome proliferator-activated receptor delta (PPARD)
ATGGAGCAGCCACAGGAGGAAGCCCCTGAGGTCCGGGAAGAGGAGGAGAAAGAGGAAGTG
GCAGAGGCAGAAGGAGCCCCAGAGCTCAATGGGGGACCACAGCATGCACTTCCTTCCAGC
AGCTACACAGACCTCTCCCGGAGCTCCTCGCCACCCTCACTGCTGGACCAACTGCAGATG
GGCTGTGACGGGGCCTCATGCGGCAGCCTCAACATGGAGTGCCGGGTGTGCGGGGACAAG
GCATCGGGCTTCCACTACGGTGTTCATGCATGTGAGGGGTGCAAGGGCTTCTTCCGTCGT
ACGATCCGCATGAAGCTGGAGTACGAGAAGTGTGAGCGCAGCTGCAAGATTCAGAAGAAG
AACCGCAACAAGTGCCAGTACTGCCGCTTCCAGAAGTGCCTGGCACTGGGCATGTCACAC
AACGCTATCCGTTTTGGTCGGATGCCGGAGGCTGAGAAGAGGAAGCTGGTGGCAGGGCTG
ACTGCAAACGAGGGGAGCCAGTACAACCCACAGGTGGCCGACCTGAAGGCCTTCTCCAAG
CACATCTACAATGCCTACCTGAAAAACTTCAACATGACCAAAAAGAAGGCCCGCAGCATC
CTCACCGGCAAAGCCAGCCACACGGCGCCCTTTGTGATCCACGACATCGAGACATTGTGG
CAGGCAGAGAAGGGGCTGGTGTGGAAGCAGTTGGTGAATGGCCTGCCTCCCTACAAGGAG
ATCAGCGTGCACGTCTTCTACCGCTGCCAGTGCACCACAGTGGAGACCGTGCGGGAGCTC
ACTGAGTTCGCCAAGAGCATCCCCAGCTTCAGCAGCCTCTTCCTCAACGACCAGGTTACC
CTTCTCAAGTATGGCGTGCACGAGGCCATCTTCGCCATGCTGGCCTCTATCGTCAACAAG
GACGGGCTGCTGGTAGCCAACGGCAGTGGCTTTGTCACCCGTGAGTTCCTGCGCAGCCTC
CGCAAACCCTTCAGTGATATCATTGAGCCTAAGTTTGAATTTGCTGTCAAGTTCAACGCC
CTGGAACTTGATGACAGTGACCTGGCCCTATTCATTGCGGCCATCATTCTGTGTGGAGAC
CGGCCAGGCCTCATGAACGTTCCACGGGTGGAGGCTATCCAGGACACCATCCTGCGTGCC
CTCGAATTCCACCTGCAGGCCAACCACCCTGATGCCCAGTACCTCTTCCCCAAGCTGCTG
CAGAAGATGGCTGACCTGCGGCAACTGGTCACCGAGCACGCCCAGATGATGCAGCGGATC
AAGAAGACCGAAACCGAGACCTCGCTGCACCCTCTGCTCCAGGAGATCTACAAGGACATG
TACTAA
Chromosome Location
6
Locus
6p21.31
External Identifiers
ResourceLink
UniProtKB IDQ03181
UniProtKB Entry NamePPARD_HUMAN
GenBank Protein ID190230
GenBank Gene IDL07592
GeneCard IDPPARD
GenAtlas IDPPARD
HGNC IDHGNC:9235
PDB ID(s)1GWX, 1Y0S, 2AWH, 2B50, 2BAW, 2ENV, 2GWX, 2J14, 2Q5G, 2XYJ, 2XYW, 2XYX, 2ZNP, 2ZNQ, 3D5F, 3DY6, 3ET2, 3GWX, 3GZ9, 3OZ0, 3PEQ, 3SP9, 3TKM, 5U3Q, 5U3R, 5U3S, 5U3T, 5U3U, 5U3V, 5U3W, 5U3X, 5U3Y, 5U3Z, 5U40, 5U41, 5U42, 5U43, 5U44, 5U45, 5U46, 5XMX, 5Y7X, 5ZXI, 6A6P, 7F80, 7VWE, 7VWF, 7VWG, 7VWH, 7W0G, 7WGL, 7WGN, 8HF8, 8HUL, 8HUO
KEGG IDhsa:5467
IUPHAR/Guide To Pharmacology ID594
NCBI Gene ID5467
General References
  1. Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D, Rodan GA: Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol. 1992 Oct;6(10):1634-41. [Article]
  2. Skogsberg J, Kannisto K, Roshani L, Gagne E, Hamsten A, Larsson C, Ehrenborg E: Characterization of the human peroxisome proliferator activated receptor delta gene and its expression. Int J Mol Med. 2000 Jul;6(1):73-81. [Article]
  3. Kobayashi T, Kodani Y, Nozawa A, Endo Y, Sawasaki T: DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system. FEBS Lett. 2008 Aug 6;582(18):2737-44. doi: 10.1016/j.febslet.2008.07.003. Epub 2008 Jul 11. [Article]
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  7. van der Veen JN, Kruit JK, Havinga R, Baller JF, Chimini G, Lestavel S, Staels B, Groot PH, Groen AK, Kuipers F: Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. J Lipid Res. 2005 Mar;46(3):526-34. Epub 2004 Dec 16. [Article]
  8. Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV: Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell. 1999 Mar;3(3):397-403. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
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Sulindacapproved, investigationalunknowntargetnegative modulatorDetails
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Icosapentapproved, nutraceuticalyestargetagonistDetails
cis-Vaccenic acidexperimentalyestargetinhibitorDetails
KD3010investigationalunknowntargetDetails
Elafibranorapproved, investigationalunknowntargetagonistDetails
Bezafibrateapproved, investigationalyestargetagonistDetails
(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acidexperimentalunknowntargetDetails
2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acidexperimentalunknowntargetDetails
IndeglitazarexperimentalyestargetagonistDetails
{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acidexperimentalyestargetagonistDetails
Glycerinapproved, investigationalyestargetagonistDetails
ClinofibrateexperimentalunknowntargetDetails
Rosiglitazoneapproved, investigationalunknowntargetDetails
Troglitazoneapproved, investigational, withdrawnunknowntargetDetails
alpha-Linolenic acidapproved, investigational, nutraceuticalunknowntargetDetails
Oleic Acidapproved, investigational, vet_approvedunknowntargetDetails
CardarineinvestigationalunknowntargetagonistDetails
Phthalic AcidexperimentalunknowntargetDetails
Valproic acidapproved, investigationalunknowntargetDetails
Fenofibric acidapprovedunknowntargetunknownDetails
Fish oilapproved, nutraceuticalunknowntargetregulatorDetails
Seladelparapproved, investigationalyestargetagonistDetails
SodelglitazarinvestigationalyestargetagonistDetails
LanifibranorinvestigationalyestargetagonistDetails