Synthesis and biological evaluation of diversely substituted indolin-2-ones.

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Bouchikhi F, Rossignol E, Sancelme M, Aboab B, Anizon F, Fabbro D, Prudhomme M, Moreau P

Synthesis and biological evaluation of diversely substituted indolin-2-ones.

Eur J Med Chem. 2008 Nov;43(11):2316-22. doi: 10.1016/j.ejmech.2008.01.010. Epub 2008 Jan 25.

PubMed ID

18313174 [ View in PubMed

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Abstract

The synthesis of indolin-2-one derivatives substituted in the 3-position by an aminomethylene group bearing either an ornithine or a lysine residue is described. The inhibitory activities of these compounds toward a panel of eight kinases were examined. Furthermore, the antibacterial activities of the prepared compounds were tested against two Gram-positive bacteria Bacillus cereus and Streptomyces chartreusis, a Gram-negative bacterium Escherichia coli and a yeast Candida albicans.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Seliciclib	Cyclin-dependent kinase 2	IC 50 (nM)	700	N/A	N/A	Details