Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents.

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Lee SH, Song KS, Kim JY, Kang M, Lee JS, Cho SH, Park HJ, Kim J, Lee J

Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents.

Bioorg Med Chem. 2011 Oct 1;19(19):5813-32. doi: 10.1016/j.bmc.2011.08.014. Epub 2011 Aug 22.

PubMed ID
21906953 [ View in PubMed
]
Abstract

Novel thiophene C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different types of thiophene derivatives were readily prepared. Among the compounds tested, ethylphenyl at the distal ring 71p showed the best in vitro inhibitory activity in this series to date (IC(50)=4.47 nM) against SGLT2.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
DapagliflozinSodium/glucose cotransporter 2IC 50 (nM)0.49N/AN/ADetails