Novel 5-azaindole factor VIIa inhibitors.

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Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB

Novel 5-azaindole factor VIIa inhibitors.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3197-200. Epub 2006 Apr 18.

PubMed ID

16621549 [ View in PubMed

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Abstract

The discovery and development of 5-azaindole factor VIIa inhibitors will be described.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA	Coagulation factor VII	Ki (nM)	800	7.4	22	Details