Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.

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Rahman T, Rahmatullah M

Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. doi: 10.1016/j.bmcl.2009.11.106. Epub 2009 Nov 26.

PubMed ID

19969454 [ View in PubMed

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Abstract

Several studies have revealed piperine and a few related compounds as potent inhibitors of monoamine oxidases without delineating the underlying mechanism. Using in silico modelling, we propose a structural basis of such activity by showing that these compounds can successfully dock into the inhibitor binding pockets of human monoamine oxidase isoforms with predicted affinities comparable to some known inhibitors. The results therefore suggest that piperine can be a promising lead for developing novel monoamine oxidase inhibitors.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Harmine	Amine oxidase [flavin-containing] A	Ki (nM)	5	N/A	N/A	Details