Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.

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Yamamoto M, Ikeda S, Kondo H, Inoue S

Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):375-8.

PubMed ID

11814800 [ View in PubMed

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Abstract

The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID	Interstitial collagenase	IC 50 (nM)	3	N/A	N/A	Details