Nonbenzamidine compounds as selective factor Xa inhibitors.

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He W, Hanney B, Myers MR, Spada AP, Brown K, Colussi D, Chu V

Nonbenzamidine compounds as selective factor Xa inhibitors.

Bioorg Med Chem Lett. 2000 Aug 7;10(15):1737-9.

PubMed ID

10937736 [ View in PubMed

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Abstract

Nonbenzamidine compounds (imidazole, pyridine, pyrimidine, and thiazole derivatives) as selective serine protease factor Xa inhibitors are discussed.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE	Coagulation factor X	Ki (nM)	1.3	N/A	N/A	Details