Structure-based design of protein tyrosine phosphatase-1B inhibitors.

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Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.

PubMed ID

15863305 [ View in PubMed

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Abstract

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE	Tyrosine-protein phosphatase non-receptor type 1	IC 50 (nM)	1608000	N/A	N/A	Details
5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE	Tyrosine-protein phosphatase non-receptor type 1	IC 50 (nM)	2470	N/A	N/A	Details