Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.

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Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.

J Med Chem. 2010 Mar 25;53(6):2333-44. doi: 10.1021/jm901090b.

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20000419 [ View in PubMed

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE	Tyrosine-protein phosphatase non-receptor type 1	IC 50 (nM)	2500	N/A	N/A	Details
1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE	Tyrosine-protein phosphatase non-receptor type 1	IC 50 (nM)	1600000	N/A	N/A	Details
5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE	Tyrosine-protein phosphatase non-receptor type 1	IC 50 (nM)	2500	N/A	N/A	Details