The pharmacokinetics and availability of niflumic acid in humans.

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Houin G, Tremblay D, Bree F, Dufour A, Ledudal P, Tillement JP

The pharmacokinetics and availability of niflumic acid in humans.

Int J Clin Pharmacol Ther Toxicol. 1983 Mar;21(3):130-4.

PubMed ID
6852999 [ View in PubMed
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Abstract

The pharmacokinetic parameters and relative availability of niflumic acid in two different pharmaceutical preparations were studied in 12 subjects after a single oral administration. Total plasma clearance averaged 45 ml/min, and the half-life of elimination approximately 2 h, giving a distribution volume of 0.12 l/kg on the average. The values of these pharmacokinetic parameters were in agreement with the general characteristics of this type of substance, a weak acid strongly bound to plasma proteins. Comparison of the systemic availability of the two oral forms showed no difference; they were probably close to 100%.

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