Humoral responses to type I collagen after surgical curettage procedures employing bovine collagen implants.

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Hyder P, Singh G, Adam S

Humoral responses to type I collagen after surgical curettage procedures employing bovine collagen implants.

Biomaterials. 1992;13(10):693-6.

PubMed ID
1420714 [ View in PubMed
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Abstract

Freeze-dried bovine type I collagen was implanted into periodontally diseased sites of 11 patients in an effort to repair the affected site. Peripheral blood samples taken at 0, 6 and 12 wk were assayed for antibody to human and bovine collagen using an enzyme-linked immunosorbent assay and compared with samples from 9 control subjects. Antibody levels to both human and bovine collagen, which were present at significantly higher levels in the patients at 0 wk than in the control subjects (P less than 0.01 for human and bovine), were significantly lower at 6 wk than at zero time (P less than 0.05 and P less than 0.01 for human and bovine collagens, respectively). At 12 wk post-implantation, the antibody level to human collagen still remained significantly lower (P less than 0.05) than zero time levels but not in respect of the antibody to bovine collagen.

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