Bovine type I collagen is a collagen gel derived from cows used to treat a wide variety of wounds, as well as a supplement for bones and joints. Bovine collagen alpha-1 is a naturally occurring extracellular matrix protein which is found in tendons and other connective tissues.
- Mechanism
- Curator reviewed · 5 references
Collagen is a fibrillar protein that forms the conjunctive and connective tissues in the human body, including the skin, joints, and bones. This molecule is one of the most predominant in many living organisms, owing to its connective role in biological structures.
Collagen as a general substance is the most abundant structural protein in the human body that provides support to numerous tissues such as tendons, skin, and teeth (collagen joined to mineral crystals). All proteins that have a structure based on three helix structured polypeptidic chains. Bovine collagen is used most frequently out of naturally-sourced collagen, due to its biocompatibility with human beings.
When applied to a wound surface, bovine type I collagen absorbs wound fluid and maintains a moist wound environment, which is optimal for healing.
Numerous studies have demonstrated that the use of type I collagen matrices is capable of promoting osteogenic differentiation and mineralization of marrow stromal cells as well as human adipose stem cells. Another study demonstrated that a collagen scaffold (Gingistat) is appropriate for supporting the distribution of cells to form bone tissue.
- Primary indication
- For the management of wounds including: partial and full- thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/graft, post-Moh’s dermatological surgery, post-laser surgery, podiatric, wound dehiscence), trauma...Curator reviewed · 3 structured indications
- First approval
- United States, 2012
- Also known as
- Collagen Type I, Bovine
- Brand names
Resolves to
What you can answer from here — as of April 21, 2026
Which other approved drugs treat the same conditions as Bovine type I collagen, and which companies have late-stage candidates in those indications?
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