Clofarabine: emerging role in leukemias.

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Sampat K, Kantarjian H, Borthakur G

Clofarabine: emerging role in leukemias.

Expert Opin Investig Drugs. 2009 Oct;18(10):1559-64. doi: 10.1517/13543780903173222.

PubMed ID

19715446 [ View in PubMed

]

Abstract

Clofarabine is a second-generation purine nucleoside analogue. It works mainly by inhibiting ribonucleotide reductase and incorporating into DNA. Clofarabine has shown efficacy in selected pediatric leukemias. It has also shown significant efficacy alone and in combination with other drugs in treating adult myeloid leukemias and high-risk myelodysplastic syndromes. Further, there is significant promise for clofarabine in the treatment of older patients with acute myeloid leukemia who are unlikely to benefit from standard induction chemotherapy due to unfavorable baseline prognostic factors. An oral formulation of clofarabine is also currently under development.

DrugBank Data that Cites this Article

Drugs

Cladribine

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cladribine	DNA	Nucleotide	Humans	Yes	Other/unknown	Details
Cladribine	Ribonucleoside-diphosphate reductase large subunit	Protein	Humans	Yes	Inhibitor	Details
Cladribine	Ribonucleoside-diphosphate reductase subunit M2	Protein	Humans	Yes	Inhibitor	Details
Cladribine	Ribonucleoside-diphosphate reductase subunit M2 B	Protein	Humans	Yes	Inhibitor	Details

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Cladribine	Deoxycytidine kinase	Protein	Humans	Unknown	Substrate	Details