Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy.
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Vadivelu S, Sharer L, Schulder M
Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy.
J Neurosurg. 2010 May;112(5):920-4. doi: 10.3171/2009.8.JNS09201.
- PubMed ID
- 19731987 [ View in PubMed]
- Abstract
The authors present the case of a patient that demonstrates the long-standing use of megestrol acetate, a progesterone agonist, and its association with multiple intracranial meningioma presentation. Discontinuation of megestrol acetate led to shrinkage of multiple tumors and to the complete resolution of one tumor. Histological examination demonstrated that the largest tumor had high (by > 25% of tumor cell nuclei) progesterone-positive expression, including progesterone receptor (PR) isoform B, compared with low expression of PR isoform A; there was no evidence of estrogen receptor expression and only unaccentuated collagen expression. This is the first clinical report illustrating a causal relationship between exogenous hormones and modulation of meningioma biology in situ.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Megestrol acetate Progesterone receptor Protein Humans YesAgonistDetails