Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature.

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Wentling GK, Sevin BU, Geiger XJ, Bridges MD

Benign metastasizing leiomyoma responsive to megestrol: case report and review of the literature.

Int J Gynecol Cancer. 2005 Nov-Dec;15(6):1213-7.

PubMed ID

16343217 [ View in PubMed

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Abstract

Benign metastasizing leiomyoma (BML) is an unusual condition typically treated by surgical resection and hormonal therapy. A 37-year-old woman presented with dyspnea 6 years after uterine myomectomy. Computed tomographic scans showed pelvic and right-sided lung masses. Total abdominal hysterectomy and right salpingo-oophorectomy revealed only leiomyomas and benign ovarian cysts. Thoracotomy revealed multiple nodules consistent with leiomyomas. Estrogen and progesterone receptors on lung and uterine tissue were positive. A 21- x 18-mm residual area of neoplasm in the lung completely resolved 3 months after treatment with megestrol. The patient remains free of disease 3 years after lung resection. We present a rare case of BML in which the lung neoplasm responded to megestrol alone in the setting of intact ovarian function.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Megestrol acetate	Progesterone receptor	Protein	Humans	Yes	Agonist	Details