Adrenergic receptor subtype activation by (+)-, (-)- and (+/-)-norephedrine in the pithed rat.

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Moya-Huff FA, Maher TJ

Adrenergic receptor subtype activation by (+)-, (-)- and (+/-)-norephedrine in the pithed rat.

J Pharm Pharmacol. 1987 Feb;39(2):108-12.

PubMed ID

2881994 [ View in PubMed

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Abstract

The ability of (+/-)-norephedrine (phenylpropanolamine) and its component isomers, (+)-and (-)-norephedrine, to activate adrenergic receptor subtypes in the cardiovascular system of the urethane/chloralose-anaesthetized pithed rat has been investigated. At all adrenoceptor subtypes, (-)-norephedrine was the most potent agonist followed by (+/-)- then (+)-norephedrine. The greatest activity was observed at the alpha 1-receptor, with little activity observed at either beta 1 or beta 2-adrenoceptors. Reserpinization shifted the (-)-norephedrine dose-response curve slightly to the right, indicating that only a minor portion of its activity is due to the release of stored endogenous catecholamines. These results suggest that most of the cardiovascular activity of the compounds is through the direct activation of alpha 1-adrenoceptors.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Phenylpropanolamine	Beta-1 adrenergic receptor	Protein	Humans	Unknown	Agonist	Details
Phenylpropanolamine	Beta-2 adrenergic receptor	Protein	Humans	Unknown	Agonist	Details