Beta-2 adrenergic receptor
Details
- Name
- Beta-2 adrenergic receptor
- Synonyms
- ADRB2R
- B2AR
- Beta-2 adrenoceptor
- Beta-2 adrenoreceptor
- Gene Name
- ADRB2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037061|Beta-2 adrenergic receptor MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
- Number of residues
- 413
- Molecular Weight
- 46458.32
- Theoretical pI
- 7.44
- GO Classification
- Functionsbeta2-adrenergic receptor activity / dopamine binding / drug binding / epinephrine binding / norepinephrine binding / potassium channel regulator activity / protein homodimerization activityProcessesactivation of adenylate cyclase activity / activation of transmembrane receptor protein tyrosine kinase activity / adenylate cyclase-activating adrenergic receptor signaling pathway / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / aging / associative learning / bone resorption / brown fat cell differentiation / cell surface receptor signaling pathway / cell-cell signaling / cellular response to hypoxia / desensitization of G-protein coupled receptor protein signaling pathway by arrestin / diaphragm contraction / diet induced thermogenesis / endosome to lysosome transport / estrous cycle / excitatory postsynaptic potential / female pregnancy / heat generation / liver regeneration / mitophagy in response to mitochondrial depolarization / negative regulation of angiogenesis / negative regulation of inflammatory response / negative regulation of multicellular organism growth / negative regulation of ossification / negative regulation of platelet aggregation / negative regulation of smooth muscle contraction / negative regulation of urine volume / positive regulation of apoptotic process / positive regulation of ATPase activity / positive regulation of autophagosome maturation / positive regulation of bone mineralization / positive regulation of cell proliferation / positive regulation of lipophagy / positive regulation of MAPK cascade / positive regulation of potassium ion transport / positive regulation of protein ubiquitination / positive regulation of skeletal muscle tissue growth / positive regulation of sodium ion transport / positive regulation of the force of heart contraction by epinephrine / positive regulation of transcription from RNA polymerase II promoter / positive regulation of vasodilation / receptor-mediated endocytosis / regulation of calcium ion transport / regulation of sensory perception of pain / response to cold / response to dexamethasone / response to estrogen / response to monoamine / response to progesterone / response to testosterone / synaptic transmission, glutamatergic / vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure / wound healingComponentsapical plasma membrane / axon / dendritic spine / early endosome / endosome / integral component of plasma membrane / lysosome / neuronal cell body membrane / nucleus / plasma membrane / receptor complex / sarcolemma
- General Function
- Protein homodimerization activity
- Specific Function
- Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 35-58 72-95 107-129 151-174 197-220 275-298 306-329
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020478|Beta-2 adrenergic receptor (ADRB2) ATGGGGCAACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATAGAAGCCATGCGCCG GACCACGACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATG TCTCTCATCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAG TTCGAGCGTCTGCAGACGGTCACCAACTACTTCATCACTTCACTGGCCTGTGCTGATCTG GTCATGGGCCTGGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTTATGAAAATGTGGACT TTTGGCAACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCGTCACGGCCAGC ATTGAGACCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCAAG TACCAGAGCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTG TCAGGCCTTACCTCCTTCTTGCCCATTCAGATGCACTGGTACCGGGCCACCCACCAGGAA GCCATCAACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCC ATTGCCTCTTCCATCGTGTCCTTCTACGTTCCCCTGGTGATCATGGTCTTCGTCTACTCC AGGGTCTTTCAGGAGGCCAAAAGGCAGCTCCAGAAGATTGACAAATCTGAGGGCCGCTTC CATGTCCAGAACCTTAGCCAGGTGGAGCAGGATGGGCGGACGGGGCATGGACTCCGCAGA TCTTCCAAGTTCTGCTTGAAGGAGCACAAAGCCCTCAAGACGTTAGGCATCATCATGGGC ACTTTCACCCTCTGCTGGCTGCCCTTCTTCATCGTTAACATTGTGCATGTGATCCAGGAT AACCTCATCCGTAAGGAAGTTTACATCCTCCTAAATTGGATAGGCTATGTCAATTCTGGT TTCAATCCCCTTATCTACTGCCGGAGCCCAGATTTCAGGATTGCCTTCCAGGAGCTTCTG TGCCTGCGCAGGTCTTCTTTGAAGGCCTATGGGAATGGCTACTCCAGCAACGGCAACACA GGGGAGCAGAGTGGATATCACGTGGAACAGGAGAAAGAAAATAAACTGCTGTGTGAAGAC CTCCCAGGCACGGAAGACTTTGTGGGCCATCAAGGTACTGTGCCTAGCGATAACATTGAT TCACAAGGGAGGAATTGTAGTACAAATGACTCACTGCTGTAA
- Chromosome Location
- 5
- Locus
- 5q31-q32
- External Identifiers
Resource Link UniProtKB ID P07550 UniProtKB Entry Name ADRB2_HUMAN GenBank Protein ID 29371 GenBank Gene ID Y00106 GenAtlas ID ADRB2 HGNC ID HGNC:286 - General References
- Chung FZ, Lentes KU, Gocayne J, Fitzgerald M, Robinson D, Kerlavage AR, Fraser CM, Venter JC: Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors. FEBS Lett. 1987 Jan 26;211(2):200-6. [Article]
- Kobilka BK, Frielle T, Dohlman HG, Bolanowski MA, Dixon RA, Keller P, Caron MG, Lefkowitz RJ: Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. J Biol Chem. 1987 May 25;262(15):7321-7. [Article]
- Schofield PR, Rhee LM, Peralta EG: Primary structure of the human beta-adrenergic receptor gene. Nucleic Acids Res. 1987 Apr 24;15(8):3636. [Article]
- Kobilka BK, Dixon RA, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ: cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A. 1987 Jan;84(1):46-50. [Article]
- Emorine LJ, Marullo S, Delavier-Klutchko C, Kaveri SV, Durieu-Trautmann O, Strosberg AD: Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization. Proc Natl Acad Sci U S A. 1987 Oct;84(20):6995-9. [Article]
- Reihsaus E, Innis M, MacIntyre N, Liggett SB: Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol. 1993 Mar;8(3):334-9. [Article]
- Rupert JL, Monsalve MV, Devine DV, Hochachka PW: Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population. Ann Hum Genet. 2000 Mar;64(Pt 2):135-43. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Chung FZ, Wang CD, Potter PC, Venter JC, Fraser CM: Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation. J Biol Chem. 1988 Mar 25;263(9):4052-5. [Article]
- O'Dowd BF, Hnatowich M, Caron MG, Lefkowitz RJ, Bouvier M: Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J Biol Chem. 1989 May 5;264(13):7564-9. [Article]
- Valiquette M, Parent S, Loisel TP, Bouvier M: Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor. EMBO J. 1995 Nov 15;14(22):5542-9. [Article]
- Gurevich VV, Dion SB, Onorato JJ, Ptasienski J, Kim CM, Sterne-Marr R, Hosey MM, Benovic JL: Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors. J Biol Chem. 1995 Jan 13;270(2):720-31. [Article]
- Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowitz RJ: Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J Biol Chem. 1997 Dec 5;272(49):31051-7. [Article]
- Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M: A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature. 1999 Sep 16;401(6750):286-90. [Article]
- Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29;283(5402):655-61. [Article]
- Moffett S, Rousseau G, Lagace M, Bouvier M: The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization. J Neurochem. 2001 Jan;76(1):269-79. [Article]
- Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M: Modulation of postendocytic sorting of G protein-coupled receptors. Science. 2002 Jul 26;297(5581):615-20. [Article]
- Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. [Article]
- Berthouze M, Venkataramanan V, Li Y, Shenoy SK: The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. EMBO J. 2009 Jun 17;28(12):1684-96. doi: 10.1038/emboj.2009.128. Epub 2009 May 7. [Article]
- Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS: Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Sci Signal. 2009 Jul 7;2(78):ra33. doi: 10.1126/scisignal.2000444. [Article]
- Nabhan JF, Pan H, Lu Q: Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor. EMBO Rep. 2010 Aug;11(8):605-11. doi: 10.1038/embor.2010.80. Epub 2010 Jun 18. [Article]
- Lauffer BE, Melero C, Temkin P, Lei C, Hong W, Kortemme T, von Zastrow M: SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J Cell Biol. 2010 Aug 23;190(4):565-74. doi: 10.1083/jcb.201004060. [Article]
- Temkin P, Lauffer B, Jager S, Cimermancic P, Krogan NJ, von Zastrow M: SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol. 2011 Jun;13(6):715-21. doi: 10.1038/ncb2252. Epub 2011 May 22. [Article]
- Qi S, O'Hayre M, Gutkind JS, Hurley JH: Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci. 2014 Dec;23(12):1708-16. doi: 10.1002/pro.2549. Epub 2014 Sep 26. [Article]
- Sauvageau E, Rochdi MD, Oueslati M, Hamdan FF, Percherancier Y, Simpson JC, Pepperkok R, Bouvier M: CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum. Traffic. 2014 Apr;15(4):383-400. doi: 10.1111/tra.12148. Epub 2014 Feb 6. [Article]
- Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK: Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature. 2007 Nov 15;450(7168):383-7. Epub 2007 Oct 21. [Article]
- Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC: High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science. 2007 Nov 23;318(5854):1258-65. Epub 2007 Oct 25. [Article]
- Hanson MA, Cherezov V, Griffith MT, Roth CB, Jaakola VP, Chien EY, Velasquez J, Kuhn P, Stevens RC: A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure. 2008 Jun;16(6):897-905. doi: 10.1016/j.str.2008.05.001. [Article]
- Green SA, Turki J, Innis M, Liggett SB: Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. 1994 Aug 16;33(32):9414-9. [Article]
- Turki J, Pak J, Green SA, Martin RJ, Liggett SB: Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. J Clin Invest. 1995 Apr;95(4):1635-41. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00521 Carteolol approved yes antagonist Details DB00816 Orciprenaline approved yes agonist Details DB00867 Ritodrine approved, investigational yes agonist Details DB00871 Terbutaline approved yes agonist Details DB00901 Bitolterol withdrawn yes Details DB00938 Salmeterol approved yes agonist Details DB00983 Formoterol approved, investigational yes agonist Details DB01001 Salbutamol approved, vet_approved yes agonist Details DB00373 Timolol approved yes antagonist Details DB00571 Propranolol approved, investigational unknown antagonist Details DB00598 Labetalol approved yes antagonist Details DB00612 Bisoprolol approved no antagonist Details DB00668 Epinephrine approved, vet_approved yes agonist Details DB00852 Pseudoephedrine approved unknown partial agonist Details DB00866 Alprenolol experimental, withdrawn yes antagonist Details DB00960 Pindolol approved, investigational yes partial agonist Details DB01064 Isoprenaline approved, investigational yes agonistbinder Details DB01151 Desipramine approved, investigational unknown antagonist Details DB01203 Nadolol approved unknown antagonist Details DB01210 Levobunolol approved yes antagonist Details DB01214 Metipranolol approved yes antagonist Details DB01274 Arformoterol approved, investigational yes agonist Details DB01366 Procaterol approved, investigational yes agonist Details DB01407 Clenbuterol approved, investigational, vet_approved yes agonist Details DB01136 Carvedilol approved, investigational unknown antagonist Details DB01288 Fenoterol approved, investigational yes agonist Details DB01291 Pirbuterol approved yes agonist Details DB01580 Oxprenolol approved unknown antagonist Details DB01359 Penbutolol approved, investigational yes antagonistpartial agonist Details DB00368 Norepinephrine approved yes agonist Details DB01408 Bambuterol investigational yes agonist Details DB05039 Indacaterol approved yes agonist Details DB05849 NCX 950 investigational unknown Details DB06262 Droxidopa approved, investigational yes agonist Details DB00264 Metoprolol approved, investigational no antagonist Details DB00195 Betaxolol approved, investigational unknown antagonist Details DB00489 Sotalol approved yes antagonist Details DB01295 Bevantolol experimental unknown antagonist Details DB01193 Acebutolol approved, investigational unknown partial agonist Details DB01102 Arbutamine approved unknown agonist Details DB00841 Dobutamine approved unknown agonist Details DB07543 (S)-carazolol experimental unknown Details DB00449 Dipivefrin approved yes agonist Details DB08807 Bopindolol experimental unknown partial agonist Details DB08808 Bupranolol experimental unknown antagonist Details DB04861 Nebivolol approved, investigational unknown antagonist Details DB00925 Phenoxybenzamine approved unknown Details DB01363 Ephedra sinica root nutraceutical yes agonist Details DB06216 Asenapine approved unknown antagonist Details DB00248 Cabergoline approved unknown binder Details DB00221 Isoetharine approved unknown agonist Details DB00335 Atenolol approved unknown antagonist Details DB00397 Phenylpropanolamine approved, vet_approved, withdrawn unknown agonist Details DB09080 Olodaterol approved yes agonist Details DB09082 Vilanterol approved yes agonist Details DB04846 Celiprolol approved, investigational yes agonist Details DB13139 Levosalbutamol approved, investigational yes agonist Details DB09013 Befunolol experimental unknown Details DB12248 Tulobuterol investigational unknown regulator Details DB01917 Putrescine experimental unknown Details DB03566 Spermidine experimental unknown Details DB00127 Spermine experimental, nutraceutical unknown Details DB01182 Propafenone approved unknown antagonist Details DB09204 Arotinolol investigational yes antagonist Details DB09273 Doxofylline experimental yes agonist Details DB06814 Protokylol approved, vet_approved yes agonist Details DB11124 Racepinephrine approved yes agonist Details DB11587 Etafedrine approved yes agonist Details DB05590 Bedoradrine investigational yes agonist Details DB01238 Aripiprazole approved, investigational unknown ligand Details DB01364 Ephedrine approved yes agonist Details DB09185 Viloxazine approved, investigational, withdrawn unknown antagonist Details DB13624 Methoxyphenamine approved unknown regulator Details DB01118 Amiodarone approved, investigational yes inhibitordownregulator Details DB00182 Amphetamine approved, illicit, investigational unknown agonist Details DB00540 Nortriptyline approved unknown antagonist Details DB00726 Trimipramine approved unknown binder Details DB00334 Olanzapine approved, investigational no inhibitor Details DB00217 Bethanidine approved unknown antagonist Details DB01365 Mephentermine approved unknown agonist Details DB06726 Bufuralol experimental unknown antagonist Details DB13345 Dihydroergocristine approved, experimental yes antagonistagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB11278 DL-Methylephedrine approved yes agonist Details DB00715 Paroxetine approved, investigational unknown inhibitor Details DB00785 Cryptenamine approved unknown inhibitorpotentiator Details DB00867 Ritodrine approved, investigational yes agonistdownregulator Details DB00264 Metoprolol approved, investigational unknown inhibitor Details