Antiemetic-related dystonic reaction unmasked by removal of a scopolamine transdermal patch.

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Roberge RJ

Antiemetic-related dystonic reaction unmasked by removal of a scopolamine transdermal patch.

J Emerg Med. 2006 Apr;30(3):299-302.

PubMed ID
16677982 [ View in PubMed
]
Abstract

A case of a dystonic reaction is presented that occurred after the use of prochlorperazine, metoclopramide and ondansetron for the treatment of post-operative nausea and vomiting. The onset of dystonia coincided temporally with the removal of a transdermal scopolamine patch used as adjunctive antiemetic therapy. Withdrawal of concurrently administered anticholinergic medication, after recent use of antiemetic medications with dopamine receptor (D2) inhibition, can unmask a dystonic reaction. This case also suggests that transdermal scopolamine may offer an innovative therapy for the treatment of acute dystonic reactions.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
ProchlorperazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details