Prochlorperazine is a phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. It mainly works by depressing the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain.
- Mechanism
- Curator reviewed · 4 references
The mechanism of action of prochlorperazine has not been fully determined, but may be primarily related to its anti-dopaminergic effects. Prochlorperazine blocks the D2 dopamine receptors in the brain, which are somatodendritic autoreceptors. Inhibition of D2 receptor signaling results in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Nausea and vomiting are proposed to arise from peripheral or central stimulation of serotonin type 3 (5-HT3) and dopamine type 2 receptors, the predominant receptors expressed at the chemoreceptor trigger zone (CTZ). Prochlorperazine exerts antiemetic effects and was shown to inhibit apomorphine-induced vomiting by blocking D2 dopamine receptors in the CTZ..
- Primary indication
- Indicated for the symptomatic treatment of severe nausea and vomiting.Curator reviewed · 5 structured indications
- Formula / weight
- C20H24ClN3S · 373.943 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1956
- Also known as
- Capazine · Chlormeprazine · Chloropernazine · Prochlorpermazine · Prochlorpromazine
- Code names
- Bayer A 173 · RP 6140 · SKF 4657
- Brand names
Resolves to
WIKYUJGCLQQFNW-UHFFFAOYSA-NSMILESCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(Cl)C=C3)CC1What you can answer from here — as of September 23, 2026
Which drugs share a target with Prochlorperazine, and which of those have an active Phase 3 trial?
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