The structure of human carbonic anhydrase II in complex with bromide and azide.
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Jonsson BM, Hakansson K, Liljas A
The structure of human carbonic anhydrase II in complex with bromide and azide.
FEBS Lett. 1993 May 10;322(2):186-90.
- PubMed ID
- 8482389 [ View in PubMed]
- Abstract
The three-dimensional structure of human carbonic anhydrase II complexed with azide and with bromide was investigated crystallographically. Both of these non-protonated inhibitors replace the zinc and the 'deep' water, two catalytically important water molecules in the active site of the molecule. Both the azide and the bromide ions bind in a distorted tetrahedral manner 0.4 and 1.1 A from the zinc water position, respectively, but are in close contact (2.0 and 2.6 A, respectively) with the zinc ion.