Respiratory and sedative effects of clobazam and clonazepam in volunteers.

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Wildin JD, Pleuvry BJ, Mawer GE, Onon T, Millington L

Respiratory and sedative effects of clobazam and clonazepam in volunteers.

Br J Clin Pharmacol. 1990 Feb;29(2):169-77.

PubMed ID
2106335 [ View in PubMed
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Abstract

1. The respiratory and psychomotor effects of two benzodiazepines used mainly as anticonvulsants were compared in healthy volunteers, using a double-blind placebo controlled design. 2. Clobazam (10 and 20 mg) produced significantly fewer psychomotor side effects than clonazepam (0.5 and 1 mg). Neither drug at either dose affected the ventilatory response to CO2. 3. Although clonazepam produced significant effects on psychomotor performance, these did not correlate with plasma drug concentration. 4. Our studies provide further evidence that at the doses chosen clobazam is considerably less sedating than clonazepam. Further investigation is required into the tolerance profile of both drugs in patients.

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