Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.
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Saltzman AG, Morse B, Whitman MM, Ivanshchenko Y, Jaye M, Felder S
Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.
Biochem Biophys Res Commun. 1991 Dec 31;181(3):1469-78.
- PubMed ID
- 1722404 [ View in PubMed]
- Abstract
We report the cloning and the deduced amino acid sequence of cDNAs encoding both the human serotonin 5-HT2 and 5-HT1C receptors. The human 5-HT2 and 5-HT1C receptors shared 87% and 90% amino acid homology, respectively, with their rat counterparts. The most divergent regions of the 5-HT2 receptor between human and rat were the N-terminal extracellular domain (75% homology) and the C-terminal intracellular domain (67% homology between amino acids 426-474). The greatest variability between the human and rat 5-HT1C receptors were at the N-terminal extracellular domain (78% homology) and the third cytoplasmic loop (71% homology). The availability of the cloned human 5-HT2 and 5-HT1C receptors will help facilitate the further understanding of the molecular pharmacology and physiology of these receptors.