Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase.
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Faison LD, White HL
Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase.
Prostaglandins. 1992 Sep;44(3):245-9.
- PubMed ID
- 1357724 [ View in PubMed]
- Abstract
Sulfasalazine produced a dose-dependent inhibition of the enzymatic synthesis of platelet-activating factor (PAF) in lysates of rat pleural neutrophils, with an IC50 of 50 microM. Major metabolites of sulfasalazine, 5-aminosalicylic acid and sulfapyridine, inhibited this enzymatic synthesis at much higher concentrations. Inhibition of arachidonate 5-lipoxygenase by sulfasalazine and its major metabolites was also observed at higher concentrations (2-3 mM). Because PAF is a potent mediator of inflammatory responses, an inhibition of PAF synthesis by sulfasalazine may contribute to its therapeutic actions in conditions such as ulcerative colitis and rheumatic illnesses.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Sulfasalazine Acetyl-CoA acetyltransferase, mitochondrial Protein Humans YesInhibitorDetails