X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride.

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Llacer JM, Gallardo V, Delgado R, Parraga J, Martin D, Ruiz MA

X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride.

Drug Dev Ind Pharm. 2001 Oct;27(9):899-908.

PubMed ID

11763467 [ View in PubMed

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Abstract

Using different techniques, we studied the possible formation of ondansetron polymorphs. Ondansetron is a carbazol antiemetic that acts as a competitive, selective inhibitor of 5-HT3 serotonin receptors. The polymorphs were determined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results suggest that the compounds are not true crystallographic polymorphs, but instead are the product of physical structural changes in the drug, which would be of interest pharmaceutically.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ondansetron	5-hydroxytryptamine receptor 3A	Protein	Humans	Yes	Antagonist	Details