Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants.

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Watts P, Satterfield D, Lim MK

Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants.

J AAPOS. 2007 Jun;11(3):282-3.

PubMed ID

17572343 [ View in PubMed

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Abstract

Apraclonidine, a selective alpha(2)-agonist, was developed to lower intraocular pressure and minimize the systemic side effects associated with the use of its parent drug, clonidine.(1) An investigation of the site of action of apraclonidine incidentally uncovered a reversal of anisocoria in patients with absent sympathetic innervation of one pupil (Horner syndrome) due to its alpha(1)-effect on a pupil with denervation supersensitivity.(2) It has been used as a diagnostic test for Horner syndrome.(3,4) We report adverse effects of topical apraclonidine when used in the diagnosis of Horner syndrome in infants.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Apraclonidine	Alpha-1A adrenergic receptor	Protein	Humans	Yes	Agonist	Details
Apraclonidine	Alpha-2A adrenergic receptor	Protein	Humans	Yes	Agonist	Details