Apraclonidine is an alpha adrenergic agonist used to treat raised intraocular pressure. Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy.
- Mechanism
- Curator reviewed
Apraclonidine is a relatively selective alpha2 adrenergic receptor agonist that stimulates alpha1 receptors to a lesser extent. It has a peak ocular hypotensive effect occurring at two hours post-dosing. The exact mechanism of action is unknown, but fluorophotometric studies in animals and humans suggest that Apraclonidine has a dual mechanism of action by reducing aqueous humor production through the constriction of afferent ciliary process vessels, and increasing uveoscleral outflow.
- Primary indication
- For prevention or reduction of intraoperative and postoperative increases in intraocular pressure (IOP) before and after ocular laser surgery when used prophylactically.Curator reviewed · 3 structured indications
- Formula / weight
- C9H10Cl2N4 · 245.109 g/mol (avg)
- First approval
- Canada, 2023 · United States, 1988
- Also known as
- 4-Aminoclonidine
- Brand names
Resolves to
IEJXVRYNEISIKR-UHFFFAOYSA-NSMILESNC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Apraclonidine, and which of those have an active Phase 3 trial?
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