Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

Article Details

Citation

Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, Narula SK

Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

Nature. 1995 Jul 20;376(6537):230-5.

PubMed ID
7617032 [ View in PubMed
]
Abstract

The crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 A. Upon receptor binding, the flexible AB loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Interferon gamma receptor 1P15260Details
Interferon gammaP01579Details