A family of human cdc2-related protein kinases.

Article Details


Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH

A family of human cdc2-related protein kinases.

EMBO J. 1992 Aug;11(8):2909-17.

PubMed ID
1639063 [ View in PubMed

The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell cycle. We have identified 10 human protein kinases based on their structural relation to p34cdc2. Seven of these kinases are novel and the products of five share greater than 50% amino acid sequence identity with p34cdc2. The seven novel genes are broadly expressed in human cell lines and tissues with each displaying some cell type or tissue specificity. The cdk3 gene, like cdc2 and cdk2, can complement cdc28 mutants of Saccharomyces cerevisiae, suggesting that all three of these protein kinases can play roles in the regulation of the mammalian cell cycle. The identification of a large family of cdc2-related kinases opens the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins.

DrugBank Data that Cites this Article

NameUniProt ID
Cyclin-dependent-like kinase 5Q00535Details
Cyclin-dependent kinase 6Q00534Details
Cyclin-dependent kinase 16Q00536Details
Cyclin-dependent kinase-like 1Q00532Details
Cyclin-dependent kinase 17Q00537Details