Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

Article Details

Citation

Hottiger MO, Hassa PO, Luscher B, Schuler H, Koch-Nolte F

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

Trends Biochem Sci. 2010 Apr;35(4):208-19. doi: 10.1016/j.tibs.2009.12.003. Epub 2010 Jan 26.

PubMed ID
20106667 [ View in PubMed
]
Abstract

ADP-ribosylation is a post-translational modification of proteins catalyzed by ADP-ribosyltransferases. It comprises the transfer of the ADP-ribose moiety from NAD+ to specific amino acid residues on substrate proteins or to ADP-ribose itself. Currently, 22 human genes encoding proteins that possess an ADP-ribosyltransferase catalytic domain are known. Recent structural and enzymological evidence of poly(ADP-ribose)polymerase (PARP) family members demonstrate that earlier proposed names and classifications of these proteins are no longer accurate. Here we summarize these new findings and propose a new consensus nomenclature for all ADP-ribosyltransferases (ARTs) based on the catalyzed reaction and on structural features. A unified nomenclature would facilitate communication between researchers both inside and outside the ADP-ribosylation field.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1P52961Details
Poly [ADP-ribose] polymerase 1P09874Details
Poly [ADP-ribose] polymerase 2Q9UGN5Details
Protein mono-ADP-ribosyltransferase PARP3Q9Y6F1Details
Protein mono-ADP-ribosyltransferase PARP15Q460N3Details