Triflusal: an antiplatelet drug with a neuroprotective effect?

Article Details

Citation

Copy to clipboard

Gonzalez-Correa JA, De La Cruz JP

Triflusal: an antiplatelet drug with a neuroprotective effect?

Cardiovasc Drug Rev. 2006 Spring;24(1):11-24.

PubMed ID

16939630 [ View in PubMed

]

Abstract

Triflusal is a derivative of salicylic acid with a well-established platelet aggregation inhibitory profile. Its pharmacokinetic and pharmacodynamic properties differ, however, somewhat from those of acetylsalicylic acid. A number of recent experimental and clinical studies have shown that triflusal is a potentially useful choice in the treatment and prophylaxis of brain ischemia because of its antithrombogenic as well as neuroprotective effects. Its antithrombogenic effect has been demonstrated at the clinical as well as at the experimental level, while its neuroprotective effect has been shown only in experimental models. The drug interferes with thrombogenesis by inhibiting thromboxane synthesis and increasing the levels of cAMP and nitric oxide. Its neuroprotective action is the result of its antioxidant and antiinflammatory effects in brain tissue. From a clinical standpoint triflusal is similar in efficacy to acetylsalicylic acid in preventing stroke, but has less adverse effects, especially it is less likely to cause bleeding. Because of its pharmacodynamic properties and lower rate of adverse reactions, triflusal may be a useful alternative to acetylsalicylic acid in the prevention of stroke.

DrugBank Data that Cites this Article

Drugs

Triflusal

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Triflusal	Nitric oxide synthase, inducible	Protein	Humans	Yes	Agonist	Details