Development of a non-surfactant formulation for alfaxalone through the use of chemically-modified cyclodextrins.

Article Details

Citation
Copy to clipboard

Brewster ME, Estes KS, Bodor N

Development of a non-surfactant formulation for alfaxalone through the use of chemically-modified cyclodextrins.

J Parenter Sci Technol. 1989 Nov-Dec;43(6):262-5.

PubMed ID
2600731 [ View in PubMed
]
Abstract

The poor water solubility of alfaxalone (less than 5 micrograms/mL), a useful steroid anesthetic agent, was dramatically increased via complexation with a series of four cyclodextrins. The most effective agent was 2-hydroxypropyl-beta-cyclodextrin (2HPCD) which solubilized alfaxalone in a linear manner as a function of concentration. At a 2HPCD concentration of 50% w/v, approximately 80 mg/mL of alfaxalone was dissolved indicating an increase in aqueous solubility of over four orders of magnitude. The cyclodextrin solution was stable to autoclaving and could be conveniently lyophilized to yield a solid product.

DrugBank Data that Cites this Article

Drugs