X-linked IAP is a direct inhibitor of cell-death proteases.

Article Details


Deveraux QL, Takahashi R, Salvesen GS, Reed JC

X-linked IAP is a direct inhibitor of cell-death proteases.

Nature. 1997 Jul 17;388(6639):300-4.

PubMed ID
9230442 [ View in PubMed

The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in regulating programmed cell death in animals ranging from insects to humans. Ectopic expression of human IAP proteins can suppress cell death induced by a variety of stimuli, but the mechanism of this inhibition was previously unknown. Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. As the caspases are highly conserved throughout the animal kingdom and are the principal effectors of apoptosis, our findings suggest how IAPs might inhibit cell death, providing evidence for a mechanism of action for these mammalian cell-death suppressors.

DrugBank Data that Cites this Article

NameUniProt ID
E3 ubiquitin-protein ligase XIAPP98170Details