Pharmacokinetics of selamectin in dogs after topical application.

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Citation

Dupuy J, Derlon AL, Sutra JF, Cadiergues MC, Franc M, Alvinerie M

Pharmacokinetics of selamectin in dogs after topical application.

Vet Res Commun. 2004 Jul;28(5):407-13.

PubMed ID
15379435 [ View in PubMed
]
Abstract

Some pharmacokinetic parameters of selamectin were determined in male (n = 5) and female (n = 5) Beagle dogs following a topical application at a dose rate of 6 mg/kg. The plasma concentration versus time data for the drug were analysed using a one-compartment model. The maximum plasma concentrations of 12.72 +/- 5.13 ng/ml for males and 22.65 +/- 11.95 ng/ml for females occurred around 5 days after administration. The area under the concentration-time curve (AUC) was 192.08 +/- 63.85 ng.day/ml for males and 370.97 +/- 146.87 ng.day/ml for females. The mean residence time was the same in males and females (12.55 days). This study reveals a sex-influence on the disposition of selamectin in the plasma of dogs, which implies that further information will be needed for correlation with efficacy studies in dogs.

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