New (fluorescent) light on poliovirus entry.
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Bergelson JM
New (fluorescent) light on poliovirus entry.
Trends Microbiol. 2008 Feb;16(2):44-7. doi: 10.1016/j.tim.2007.12.004. Epub 2008 Jan 10.
- PubMed ID
- 18191571 [ View in PubMed]
- Abstract
To initiate infection, poliovirus must release its RNA genome into the cytoplasm of a target cell, a process called 'uncoating'. How this occurs has remained uncertain, despite studies over several decades. Two new studies re-address the question of poliovirus entry. The results suggest that poliovirus enters different cells by different mechanisms, and point to a role for virus-induced intracellular signals in the process.