Chemical modification of tylosin. Thioether derivatives of tylosin and demycarosyltylosin.

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Omura S, Matsubara H, Tsuzuki K, Nakagawa A

Chemical modification of tylosin. Thioether derivatives of tylosin and demycarosyltylosin.

J Antibiot (Tokyo). 1984 Sep;37(9):1007-15.

PubMed ID
6501102 [ View in PubMed
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Abstract

Thioether derivatives of tylosin and demycarosyltylosin were synthesized by Michael-type addition of thiol to C-11 of the enone moiety on the aglycone. Some of tylosin derivatives were effective to macrolide resistant Staphylococcus aureus, and their in vivo activities were same or superior than that of tylosin.

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