The genome sequence of the extreme thermophile Thermus thermophilus.

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Henne A, Bruggemann H, Raasch C, Wiezer A, Hartsch T, Liesegang H, Johann A, Lienard T, Gohl O, Martinez-Arias R, Jacobi C, Starkuviene V, Schlenczeck S, Dencker S, Huber R, Klenk HP, Kramer W, Merkl R, Gottschalk G, Fritz HJ

The genome sequence of the extreme thermophile Thermus thermophilus.

Nat Biotechnol. 2004 May;22(5):547-53. Epub 2004 Apr 4.

PubMed ID
15064768 [ View in PubMed
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Abstract

Thermus thermophilus HB27 is an extremely thermophilic, halotolerant bacterium, which was originally isolated from a natural thermal environment in Japan. This organism has considerable biotechnological potential; many thermostable proteins isolated from members of the genus Thermus are indispensable in research and in industrial applications. We present here the complete genome sequence of T. thermophilus HB27, the first for the genus Thermus. The genome consists of a 1,894,877 base pair chromosome and a 232,605 base pair megaplasmid, designated pTT27. The 2,218 identified putative genes were compared to those of the closest relative sequenced so far, the mesophilic bacterium Deinococcus radiodurans. Both organisms share a similar set of proteins, although their genomes lack extensive synteny. Many new genes of potential interest for biotechnological applications were found in T. thermophilus HB27. Candidates include various proteases and key enzymes of other fundamental biological processes such as DNA replication, DNA repair and RNA maturation.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Tryptophan synthase alpha chainP16608Details
Phosphopantetheine adenylyltransferaseQ72K87Details
Tyrosine--tRNA ligaseP83453Details
Isopentenyl-diphosphate delta-isomeraseQ746I8Details
2-keto-3-deoxy-gluconate kinaseQ746L7Details
30S ribosomal protein S17P62658Details
30S ribosomal protein S20P62661Details
30S ribosomal protein S2P62662Details
30S ribosomal protein S3P62663Details
30S ribosomal protein S9P62669Details
30S ribosomal protein S19P62660Details